
Folio is a research agent for drug discovery. Give it a target protein, gene, or disease area, and it produces a structured briefing on the recent literature: top compound candidates ranked by evidence, mechanisms of action, key papers, and open questions, with every claim citing the underlying paper. The pipeline searches PubMed via E-utilities, retrieves the top abstracts, runs an extraction pass on each paper in parallel to pull compounds and mechanisms as structured JSON, then synthesises the extractions into the final briefing. Compound candidates are cross-referenced against ClinicalTrials.gov v2 so the briefing notes the highest clinical phase reached. Two Featherless models do distinct work: a small fast model handles the per-paper extraction fan-out, and a stronger model does the synthesis. Progress events stream over Server-Sent Events, so the UI updates one paper at a time as extractions finish. The source list stays visible alongside the briefing, with the full abstract and the extracted fields one click away, so a scientist can audit any cited claim back to the paper it came from. The web UI persists history per signed-in user via Supabase, exports server-side PDFs via WeasyPrint, and ships alongside a CLI for scripting and CI.
19 May 2026